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    autoSHARP is an automated structure solution pipeline. It comprises the heavy-atom refinement and phasing program SHARP, the density modification program SOLOMON, and the ARP/wARP package for automated model building and refinement (using REFMAC). SHARP (Statistical Heavy Atom Refinement And Phasing) is a program for refining a model of isomorphous or anomalous heavy-atom substitution and calculating phase probabilities.


    v. 2.6


    OSX, Linux

Documentation, Other Resources


    E. de La Fortelle & G. Bricogne (1997) "Maximum-Likelihood Heavy-Atom Parameter Refinement for the Multiple Isomorphous Replacement and Multiwavelength Anomalous Diffraction Methods" Methods in Enzymology 276 472-494. New York: Academic Press.

Last modified: 02/11/10